Acid-base status of awake rats after cannulation of aorta and vena cava

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Acid-base status of awake rats after cannulation of aorta and vena cava.

To study the extracellular acid-base equilibrium in vivo, it is necessary to obtain arterial blood samples without inducing concomitant respiratory or metabolic disturbances. Respiratory artifacts have been reported when general anesthesia had to be induced to allow the tapping of blood [1—5]. Similarly, blood collected by heart puncture or fast decapitation may not accurately reflect the acid-...

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Arterial remodeling occurs in response to mechanical and neurohumoral stimuli. We hypothesized that veins, which are not exposed to higher pressures in hypertension, would demonstrate less active remodeling than arteries. We assessed remodeling with two standard measures of arterial remodeling: vessel morphometry and the expression/function of matrix metalloproteinases (MMPs). Thoracic aorta an...

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ژورنال

عنوان ژورنال: Kidney International

سال: 1983

ISSN: 0085-2538

DOI: 10.1038/ki.1983.230